Production Of Transgenic Animals Notes

The first transgenic animal was produced in 1983 when genes for human growth hormone were introduced into mice.

Production of transgenic animals notes. Transgenic animals are being used to study gene mechanism and function to adapt pig organs to be transferred to humans to prepare recombinant pharmaceutical proteins in milk and egg white and to improve breeding and food production. Transgenic mice are developed by injecting DNA into the oocytes or 1-2 celled embryos taken from female mice. Microinjection blastocyst injection and using a retrovirus Nuclear transfers Artificial chromosomes for gene transfer PRODUCTION OF TRANSGENIC ANIMALS THE METHODOLOGY.

Methods to produce transgenic animals. Theses mechanism is absent in cell culture. The first transgenic animal was produced is mice by injecting DNA to mouse embryos then implanting the embryos in female mice.

Applications of Genetically modified animals. Studying gene function. Transgenic animals can be created by manipulating embryonic stem cells.

Transgenic animals are used as tools in research and for the production of recombinant proteins The main applications of transgenic animals are described as follows. Advantages of Transgenic Animals. One favoured method involves the inoculation of the DNA into the pronucleus of a fertilised ovum followed by implantation into pseudo pregnant females.

The foreign genes must be transmitted through the germ line so that every cell including germ cells of the animal contains the same modified genetic material. The animals used for transgenic purpose naturally carry the mechanism needed to produce complex protein. The foreign gene is constructed using recombinant DNA methodology.

43 Creation of the transgenic animal A number of methods are currently in use for the creation of transgenic animals. Transgenic animals are created-To study how genes are regulated and how they affect the normal functions of the body and its development. The transgenic animals are created because of the benefits they provide to the man.